Monday, October 20, 2008

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Hepatitis B : an oral treatment with combinations of antiviral drugs has been effective against hepatitis

A team of American researchers has successfully treated chronic hepatitis B (HBV) in marmots orally.

The researchers evaluated the antiviral effect of orally administered adefovir dipivoxil (ADV) or tenofovir disoproxil fumarate (TDF), alone or in combination with lamivudine (3TC) or emtricitabine (FTC) in marmots with chronic hepatitis viral.
It was found that the treatment administered once daily for 48 weeks with ADV more than 3TC or TDF FTC has greatly reduced viral levels from those pretreatment.

The team, comprising researchers from Cornell University and Georgetown Universtiy Medical Center, found no toxicity after administration of a drug or drug combinations.

"In conclusion, oral administration of 3TC, FTC, ADV, and TDF alone and in combination, is safe and effective in the Woodchuck model for HBV infection, the researchers said.
An article describing the study was published in the Journal Antimicrobial Agents and Chemotherapy. (ANI)


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